You know, at one point, Thanos had possession of a Cosmic Cube, used it to make himself a god...and still lost.
Now, he has the flipping Infinity Gems and accompanying Gauntlet, and he's showing off to Drax and the Silver Surfer how powerful he is now...
And he lost again.
Jim Starlin (and others) have continued to bring back Thanos again and again and again, seeking out more powerful weapons...more powerful than the gems which give you absolute control over time, space, soul, mind, power and reality? Sure, why not!! And he keeps losing.
Someday they'll realize that the continually raising the stakes from infinity to infinity plus infinity to infinity to the infinity power is just the same story over and over again, and it's always going to come out the same.
Because Thanos is a putz, and even with infinite power, he always loses.
Maybe he just needs to set his sights lower. Rule Pluto for awhile, see how that goes...
From Silver Surfer #44 (1990)